WHY NOT FINASTERIDE?
The use of finasteride for hairloss management was discovered by serendipity, not by scientific research 5 mg finasteride gives just about 7-8 % more efficiency than a 10 times lower dose of 0.2 mg. A dose of 1 mg per day was selected arbitrarily without any scientific basis, expecting that it may prevent side effects. We DO NOT use Finasteride in our treatment plan. Finasteride today has a FDA warning of permanent side effects.
Finasteride only prevents damage to the follicles. Finasteride is not a component of the structure of new hair follicle and cannot create new hair by itself. New hair in made up of iron, calcium, amino acids, B – complex, Biotin, vitamins, proteins and minerals.
In an analogy finasteride would be the traffic police to ensure smooth flow of traffic like it prevents damage to the follicle. But if you intend to go somewhere, finasteride does not take form your home to the desired destination. You need to make provisions and set out on the journey to reach your destination.
Finasteride blocks the action of DHT. but DHT is not raised in most hair loss patients. Even if finasteride blocks one mechanism of DHT formation, there are many other pathway of DHT formation and action on the cells.
Latest research shows that DHT acts by creating accumulation of free radicals in the cells which release hair growth inhibiting factor TGF-B1. This action can be successfully blocked with antioxidants and vitamins instead of using finasteride.
RECENT STUDIES ARE AGAINST THE USE OF FINASTERIDE:
- Irwig, M.S., and S. Kolukila. Persistent sexual side effects of finasteride for male pattern hair loss. J Sex Med. 2011; 8:1747-1753.
- Irwig, M.S. Persistent sexual and non-sexual adverse effects of finasteride in younger men. Sex Med Rev. 2014; 2:24-35.
- Irwig, M.S. Androgen levels and semen parameters among former users of finasteride with persistent sexual side effects. JAMA Dermatol. 2014; 150:1361-1363.
- Irwig, M.S. Depressive symptoms and suicidal thoughts among former users of finasteride with persistent sexual side effects. J Clinical Psychiatry. 2012; 73:1220-1223.
- Singh, M.K, and M. Avram. Persistent sexual dysfunction and depression in finasteride users for male pattern hair loss: a serious concern or red herring? J Clin Aesthet Dermatol. 2014; 7:51-55.
- Di Loreto, C., et al. Immunohistochemical evaluation of androgen receptor and nerve structure density in human prepuce from patients with persistent sexual side effects after finasteride use for androgenetic alopecia. PLoS One. 2014; 9:e100237.
- Ali, A.K, B.S. Heran, and M. Etminan. Persistent sexual dysfunction and suicidal ideation in young men treated with low-dose finasteride: a Pharmacovigilance study. Pharmacotherapy. 2015. doi:10.1002/phar.1612.
- Belknap, Sm., et al. Adverse event reporting in clinical trials of finasteride for androgenetic alopecia: a meta analysis. JAMA Dermatol. 2015; 151:600-606.
- Moore, T.J. Finasteride and the uncertainties of establishing harms. JAMA Dermatol. 2015; 151:586-596.
- Melcangi, R.C., and G.C. Panzica. Neuroactive steroids and the nervous system: further observations on an incomplete tricky puzzle. J Neuroendocrinol. 2012; 25:957-963.
- Caruso, D., et al. Patients treated for male pattern hair with finasteride show, after discontinuation of the drug, altered levels of neuroactive steroids in cerebrospinal fluid and plasma. J Steroid Biochem Mol Biol. 2015; 146:74-79.
Post Finasteride Syndrome is now a recognized health disorder.
TODAY AFTER 20 YEARS FDA HAS THE FOLLOWING TO SAY ABOUT FINASTERIDE:
- Finasteride studies not double blind, short term, inadequate in design
- Finasteride alters neuro-steroid levels in CSF & plasma which remain altered despite stopping the drug
- Anxiety, Depression, Sexual dysfunction have a psychic aspect unrelated caused by Finasteride, not due to reduction of DHT
- Finasteride may alter CNS, peripheral nerves or androgen signalling pathways
- Finasteride may alter an epigenetic switch, causing irreversible, permanent side effects
- Post Finasteride Syndrome is now a recognized health disorder.